Relevance—Reloaded and Recoded
نویسندگان
چکیده
منابع مشابه
Adaptive evolution of genomically recoded Escherichia coli.
Efforts are underway to construct several recoded genomes anticipated to exhibit multivirus resistance, enhanced nonstandard amino acid (nsAA) incorporation, and capability for synthetic biocontainment. Although our laboratory pioneered the first genomically recoded organism (Escherichia coli strain C321.∆A), its fitness is far lower than that of its nonrecoded ancestor, particularly in defined...
متن کاملGenomically recoded organisms expand biological functions.
We describe the construction and characterization of a genomically recoded organism (GRO). We replaced all known UAG stop codons in Escherichia coli MG1655 with synonymous UAA codons, which permitted the deletion of release factor 1 and reassignment of UAG translation function. This GRO exhibited improved properties for incorporation of nonstandard amino acids that expand the chemical diversity...
متن کاملTitle: Long-term adaptive evolution of genomically recoded Escherichia coli
Efforts are underway to construct several recoded genomes anticipated to exhibit multi-virus resistance, enhanced non-standard amino acid (NSAA) incorporation, and capability for synthetic biocontainment. Though we succeeded in pioneering the first genomically recoded organism (Escherichia coli strain C321.∆A), its fitness is far lower than that of its non-recoded ancestor, particularly in defi...
متن کاملRecoded and nonrecoded trinary signed-digit adders and multipliers with redundant-bit representations.
Highly-efficient two-step recoded and one-step nonrecoded trinary signed-digit (TSD) carry-free adders-subtracters are presented on the basis of redundant-bit representation for the operands' digits. It has been shown that only 24 (30) minterms are needed to implement the two-step recoded (the one-step nonrecoded) TSD addition for any operand length. Optical implementation of the proposed arith...
متن کاملLimits of variation, specific infectivity, and genome packaging of massively recoded poliovirus genomes.
Computer design and chemical synthesis generated viable variants of poliovirus type 1 (PV1), whose ORF (6,189 nucleotides) carried up to 1,297 "Max" mutations (excess of overrepresented synonymous codon pairs) or up to 2,104 "SD" mutations (randomly scrambled synonymous codons). "Min" variants (excess of underrepresented synonymous codon pairs) are nonviable except for P2Min, a variant temperat...
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ژورنال
عنوان ژورنال: Journal of Consumer Research
سال: 2022
ISSN: ['1537-5277', '0093-5301']
DOI: https://doi.org/10.1093/jcr/ucab074